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ARTIGO ORIGINAL

Resultado inicial após revascularização miocárdica: efeito na mortalidade e no acidente cerebrovascular

Delawer REBERI; Marcus FritzII; Alfred GermingIII; Peter MarksIV; Axel LaczkovicsV

DOI: 10.1590/S0102-76382008000100005

INTRODUCTION

The history of OPCAB (Off-Pump Coronary Artery Bypass Grafting) surgery goes back to the 1950s, where endarterectomy with saphenous vein graft was widely used [1]. In 1952, animal experiments were done with the use of the internal mammary artery to the coronary arteries [2]. Similar results could be achieved by using a saphenous vein graft to the left anterior descending artery (LAD) done by Garret, in 1964 [3]. In the same year, left internal mammary artery (LIMA) to LAD was performed by Kolesov [4]. All these operations were performed by using the off-pump technique.

At the end of the 1960s, CABG surgery with the use of extracorporeal circulation in the arrested heart was widely used, and the OPCAB surgery was more or less abandoned after the implementation of the modern cardiopulmonary bypass.

In the 1970s, Favaloro [5] reported good results with OPCAB surgery; nevertheless, CABG with cardiopulmonary bypass (CPB) remained the main technique for coronary revascularization until the end of the eighties. By then it was known that the CPB would induce whole-body inflammatory response, which causes increased mortality and morbidity [6] in addition to the trauma effect of the cannulations and its subsequent thromboembolic mechanism. However, the neurological trauma may reach 2.7%-3.1% [7].

Further development of the technologies and modification of OPCAB in the early and mid 1990s, as well as surgical and anaesthesiological improvements once again led to increased interest in that technique [8].

The purpose of this study was to show and analyse our experience in CABG with OPCAB-technique with regard to neurological trauma (stroke) and mortality.


METHODS

From January 2004 to May 2006, 252 patients were operated without cardiopulmonary bypass. The preoperative patient's characteristics are listed in Table 1.




Operative management and surgical technique

Informed consent was obtained from all patients subsequently to being properly briefed about the procedure. In order to plan the grafts all angiographies were reviewed in the early morning.

Prior to the operation all patients received their preoperative medication such as nitrates, ß-blockers, antihypertensive, ACE inhibitors and diuretics up to the time of the operation. A perfusionist was always present in the operating theatre.

Central venous catheter was inserted and electrocardiography as well as arterial pressure control was performed.

After median sternotomy, harvesting of the LIMA and saphenous vein was performed, Heparin at a dose of 300 IU/kg was administered, and activated clotting time (ACT) was maintained at a level of > 400 s. At the end of proximal anastomoses protamine was given at a dose rate of 1:1 and the effect was determined by ACT.

During the operation, aprotinin was infused with (1000, 000 KIU). To keep the patient's temperature above 35ºC the patient was placed on a warming mat throughout the operation.

A deep pericardial traction suture (LIMA-Stitch) was placed between the inferior vena cava and the left inferior pulmonary vein to facilitate the elevation of the apex of the heart and the exposure of the posterior wall of the myocardium. Stabilization of the coronary arteries was accomplished by using two different commercially available stabilization systems: OctopusTM (Medtronic, Minneapolis, MN), and Estech (OPVAC® SYNERGYTM). At the surgeon's preference intraluminal coronary shunts were inserted whenever possible or a silicon loop was used to keep the operating field bloodless. Atrial pacing was established in case of bradycardia. Distal anastomoses were performed using a continuous running 7-0 monofilament suture for the venous graft and 8-0 for the arterial grafts. Proximal anastomoses were constructed after aortic side clamping using a 6-0 running suture. In 17 patients the proximal anastomoses was reconstructed with the PAS-PORT system device (CardicaTM Inc, CA, USA).

According to the principle of functional revascularization, the anterior wall of the myocardium was bypassed first with LIMA to LAD, then right coronary artery vessel or its branches, and finally the obtuse marginal branches.

Definition of outcome parameters, data collection

Myocardial infarction (MI) was defined as the occurrence of a new Q-wave on the ECG and/or an increase of creatine kinase-MB fraction of more than 10% of the creatine kinase. Neurological injury was defined as postoperative stroke. Transient psychsyndrom was defined as minor behavioural complication.

All data was entered into a database (Microsoft) and was retrospectively analyzed. Data is presented as mean ±SD.


RESULTS

The number of grafts varied from 1-4, an average of 1.78 ±0.79 grafts per patient were done. LIMA was used in 95% of patients. The mean operation time was 132±37min. One hundred seven (42%) patients underwent one bypass graft, 99 (39%) patients received two grafts, 40 (16%) had three grafts and six (2%) had four grafts (Table 2).




Hospital mortality and morbidity

Hospital mortality was in eight (3.1) patients. The primary causes of death was myocardial infarction in one patient, sudden death in one patient, multiorgan failure in three patients, two patients died as result of sepsis, and one patient died because of pneumonia. The average EuroSCORE of the deceased patients was 10.36±6.6.

No stroke was observed, however six (2.38%) patients suffered transient psychsyndrom. Three (1.19%) patients had postoperative myocardial infarction and there were significant arrhythmias (atrial fibrillation) in 38 (15%) patients. Rethoracotomy as a result of bleeding in two (0.8%) patients, the mean use of blood units was 1.86±3.6, there were four (1.59%) deep wound infections requiring surgical intervention (Table 3).




DISCUSSION

Controversy still exists concerning the clinical outcome of OPCAB patients with regard to morbidity and mortality in elderly patients with multiple comorbidities and whether or not OPCAB is superior to conventional CABG.

Surgical techniques are constantly in development, such as establishing the OPCAB procedure and developing innovative techniques such as stabilizers, intracoronary shunts to induce bloodless field, better intraoperative coordination with anaesthesiologists and better monitoring. All these resulted in excellent performance of anastomosis in multivessel disease without CPB [9].

The average age of our patient population was 70 years, 48 (19%) were >80 years old. We evaluated our risk prediction by using the European System for Cardiac Operative Risk Evaluation (EuroSCORE) [10]. The average EuroSCORE in all of our patients was 5.1±3.8. We registered a hospital mortality of 3.1%.

CABG on the beating heart in elderly patients is controversially debated in the literature. Some studies concluded to have lower morbidity and mortality [11]. In an earlier study done by our group as well as in other studies no significant difference in terms of mortality were found [12,13].

In this study our postoperative results with regard to perioperative morbidity was relatively low in terms of myocardial infarction (1.19%), blood transfusions (1.8%), rethoracotomy as a result of bleeding (0.8%) and deep sternal wound infection (1.59%). Our results are somewhat similar to those found in the literature [14,15].

In a multi-centre study performed by the group of M. Mack [16] it was determined that there is a 73% higher mortality rate in females compared to males. We have similar result in this study, Six out of eight of our deceased patients were females.

We are of the same opinion as Kilo et al. [17] whether or not the complete revascularization in elderly patients is justified. They found that in elderly patients the incomplete revascularization OPCAB may yield better operative results than complete revascularization on-pump. Perioperative complications were more frequent and midterm survival was worse in the on-pump patient group.

One of the major and devastating complications after CABG surgery is stroke; it results in disability of the patient and prolonged hospital stay and costs.

In our study there was a 0% stroke rate. Almost all authors in the literature will agree that patients receiving the OPCAB procedure were less likely to have a stroke rate in comparison with the conventional CABG, and the stroke rate remains low even in high-risk patients [18,19].

One of the most predictors of stroke after CABG is manipulation of ascending thoracic aorta which may be atherosclerotic which leads to release atheromatose and calcific debris which can embolize to the brain [20].

OPCAB surgery may avoid these complications because it has a potential to reduce the need for aortic manipulation and it is associated with reduced level of S-100 protein as compared to conventional CABG [21].

It is clear that "no touch aorta" operative technique in severely atherosclerotic cases results in fewer neurological complications. One hundred and seven of our patients have no touch aorta.

Other postulations for neurological deficits are embolization of fat particles, air bubbles and fibroelastom tissues [22].

Zamvar et al. [23], who performed a randomized controlled trial, found less neurological adverse events in the OPCAB group than with the conventional CABG.

Some are doing routine intraoperative transesophageal echocardiography which have showed to be safe and accurate to evaluate the extension of the aortic calcification. Sharony et al. [24] showed significant reduction of stroke in the group of OPCAB compared to conventional CABG.

OPCAB also shows reduced coagulation impairment and similarly other studies reported reduced inflammatory response after off-pump surgery [25].

In the past years, we have learned to find an appropriate surgical strategy and to properly select patients who may possibly benefit from OPCAB.

Our selection criteria of patients for OPCAB is diseased aorta ascendens (no touch aorta or proximal anastomosis device with PAS-PORT system), advanced age >75 years and patients with sever comorbidity, particularly in patients with preoperative neurological deficits.

A plane X-ray should be done preoperatively in which sometimes you can determine the extension of the atheromatose ascending aorta.

However the choice of appropriate surgical strategy depends on patient's clinical status and surgeon's experience.

A screening carotid ultrasonography will be performed in all patients who undergo CABG in our department. According to the grade of stenosis and neurological symptoms we will achieve carotid endarterectomy first and after a week the CABG operation in OPCAB technique, this has been done in two of our patients.

We believe that OPCAB in experienced hands is beneficial and yields better results, particularly in elderly patients.

It is a limitation of this study that it is retrospective and does not refer to patency with randomized angiography and midterm outcome. A randomized comparative study with conventional CABG is needed.


CONCLUSION

CABG with OPCAB technique demonstrates low mortality and morbidity in terms of Stroke. The advantages of this technique depends on the patient's general condition at the time of the operation, the sufficiency of pump function and coronary morphology, as well as on the surgeon's experience.


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